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Y. application. Mathias, M. J. Welch, W. L. Madsen and A. E. Martell. Transition metal complexes find their application in catalysis, material synthesis, photochemistry, therapy, and diagnostics. M. L. Thakur, R. E. Coleman and M. J. Welch. The application of this field to biomedical uses is dealt with in 5 chapters. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. S. Kojima, K. Kaminaka, M. Kiyozumi and T. Honda. Major work horses are those derived from polypyridine complexes and metalloporphyrins. Tao, Y.-Y. A coordination complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents. HeadquartersIntechOpen Limited5 Princes Gate Court,London, SW7 2QJ,UNITED KINGDOM. 1. There are a number of ways in which coordination compounds are used in the analysis of various substances. It is estimated that approximately half of all proteins contain a metal. Many metal-containing compounds, especially those of transition metals, are coordination complexes. M. W. Brechbiel, T. J. McMurry and O. M. Gyparaki, J. Wells, A. E. Martell and M. J. Welch. Other techniques such as elemental analysis, electrochemical, and thermal methods were also employed for the assessment of the complexation ratio. S. Jurisson, E. A. Schlemper, D. E. Troutner, L. R. Canning, L. R. D. P. Nowotnik and R. D. Neirinckx, In: U. Mazzi, E. Roncair, G. Bandoli and L. Magon. Both of these factors are important in biological systems because of the fact that all metal ions are subject to interaction with the natural ligands that are present in body fluids for the purpose of storage, transport and the regulation of the activity of natural metal ions … Many studies were conducted concerning the synthesis and the investigation of metal complexes in which the pharmaceutical substances play the role of ligand highlighting their increasing clinical and commercial importance. Transition metals complex under goes a series of reactions that are generally unlike those main group compounds. We here review the properties of five metal complexes as anticancer agents and make comparisons among them in biological features and cytotoxic activity. E. R. Stine, C.-A. D. Brenner, A. Davison, J. Lister-Jones and A. G. Jones. G. J. Kontoghiorghes and A. V. Hoffbrand. C. J. Mathias, M. J. Welch, M. R. Raichle, M. A. Mintun, L. L. Lick, A. H. McGuire, K. R. Zinn, E. K. John and M. A. P. L. Carney, P. E.; Rogers and K. D. Johnson. Y.-Y. I. G. R. Gale, A. Metal complexes can be used either for radioisotope imaging (from their emitted radiation) or as contrast agents, for example, in magnetic resonance imaging (MRI). Transition metals are applied in the organic reactions. D. J. P. W. Durbin, N. Jeung, S. J. Rodgers, P. N. Turowski, F. L. Weitle, D. L. White and K. N. Raymond. Metal ions are of great importance not only in the vital functions of living organisms, but also they can be intensively used in analysis and control methods for pharmaceutical substances by forming complexes that can be detected by using different physicochemical methods such as spectroscopy, chromatography, microscopy, etc. Unable to display preview. Metals Application A. Not affiliated 1–12. It will be the philosophy of this chapter that the thermodynamic stability of a metal chelate should be maximized, and the principles described in this book will be used for this purpose. E. J. Shherrard, J. V. Walker and J. L. Boykin. Xu, Y.-Z. Chen, M.-Z. Figure 25.6. Hsu, T. D. Hoover, H. V. Aposhian and D. E. Carter. Sun, R. J. Motekaitis and A. E. Martell. Metal complexes have become an emerging tool in drug discovery being widely used as therapeutic compounds to treat several human diseases such as carcinomas, lymphomas, infection control, diabetes, anti-inflammatory, and neurological disorders [8, 9]. B. Porter and E. R. Huehns. Coverage of other precious metals includes gold, ruthenium (currently two complexes in clinical anticancer trials), palladium (much more kinetically labile than platinum, currently the subject of research) and rhodium (anticancer potential). D. P. Nowotnik, L. R. Canning and S. A. Cumming. properties of transition metal complexes [7]. Non-platinum complexes (like Fe, Pd, Ru, Cu, Bi, Zn, etc.) Sun, J. M. Connet, G. W. Philpott, M. J. Welch and A. E. Martell. J. L. Domingo, M. Gomez, J. M. Llobet and J. Corbella. Sun, C. J. Anderson, T. S. Pajeau, D. E. Reichert, R. D. Hancock, R. J. Motekaitis, A. E. Martell, and M. J. Welch. Contrast agens in diagnostic. H. V. Aposhian, C. H. Tadlock and T. E. Moon. D. R. Burton, S. Forsen and G. Karlstrom. Clonidine (CLN) (2[(2,6-dichlorophenyl)imino]-imidazolidine) is a centrally acting α2 adrenergic agonist used as antihypertensive drug. 1. Hsieh, W.-Z. However, high thermodynamic stability and selectivity are not the sole requirements of the ligand or of the metal complex being considered, because there are many other factors in biological systems which must be taken into consideration. H. V. Aposhian, D. E. Carter, T. D. Hoover, C.-H Hsu, R. M. Maiorino and E. Stein. G. L. DeNardo, S. J. DeNardo and J. S. Peng. S. I. Kang, R. S. Ranganathan, J. E. Emswiler, K. Kumar, J. [Application of metal ions and their complexes in medicine II. Various chemical, optical, and magnetic properties of the metal complexes of some pharmaceutical substances (pyrazinamide, nicotinamide, nicotinic acid, tolbutamide, theophylline, captopril, clonidine, and guanfacine) have been studied by using a wide range of techniques. When a ligand is designed to remove a certain metal ion because it has reached toxic levels, it must be as selective as possible for that metal ion so as not to disturb the metals that are naturally present. Xie. R. Ma, J. Reibenspies, M. J. Welch and A. E. Martell. J. P. Lavender, J. Lowe and J. R. Barker. C. J. Anderson, C. S. John, Y. J. Li, R. D. Hancock, T. J. McCarthy, A. E. Martell and M. J. Welch. R. J. Alfidi, J. R. Haaga Jr. and S. J. El Yousef. C. J. Mathias, Y. S. W. Schwarz, C. J. Mathias, Y. Silver, J. were found with potential anticancer activities. M. Misra, M. Athar, S. K. Hasan and R. C. Srinivastava. E. N. Treher, L. C. Francesconi, J. A. Ortega, J. L. Domingo, M. Gomez and J. Corbella. The scanning electron microscopy images revealed the morphology of the metal complexes underlying their crystalline or amorphous character. E. R. Huehns, J. Sun, R. J. Motekaitis, A. E. Martell and M. J. Welch. P. W. Durbin, N. Jueng, E. S. Jones, F. L. Weitl and K. N. Raymond. G. Bandoli, M. Nicolini, U. Mazzi, H. Spies, and R. Munze. pp 149-197 | More than 140 copper complexes of non-steroidal anti-inflammatory agents (aspirin and ibuprofen, for example) have been shown to be more active than their parent compounds. Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. A. Koutcher, C. T. Burt, R. B. Lauffer and T. J. Brady. ), bioavailability, membrane permeability, toxicity, and rapid elimination of the ligand and its metal chelate without spreading the undesired metal to other organs throughout the body. G. J. Kontoghiorghes, L. Sheppard and S. Chambers. L. A. Learie, R. C. Holtiwanger and C. G. Pierpont. Available from: Physicochemical characterization of metal complexes of some pharmaceuticals, Biomedical significance of metal complexes with pharmaceuticals, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania. Y. M. Streater, P. D. Taylor, R.C. Organometallic chemistry is the study of interaction between metal cations and ligands. Y. The FTIR spectral studies indicated that the three mentioned complexes were coordinated through the carbonyl group. It is well known that many molecules of drug substances act as ligands both in vitro and in vivo conditions. L. Carlton, R. D. Hancock, H. Maumela and K. P. Wainwright. We have known enough about these compounds already, including their structuresand isomers etc. S. Jurisson, D. Berning, W. Jia and D. Ma. M. J. Sundberg, C. F. Meares and D. A. Goodwin. 2H2O, and [Cu(TBA)2][Hg(SCN)4].H2O and then were characterized by elemental analysis, FTIR spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and thermal methods establishing the combination ratio Cu:TBA 1:2, the presence of water of crystallization, and the coordination system. The success of the clinical uses of cisplatin, cis - [Pt II (NH 3) 2 Cl 2 ], has stimulated considerable interest in using other metal complexes as new therapeutic agents. A. Clanton and D. M. Lukehart. R. B. Lauffer, W. L. Greif, D. D. Stark, A. C. Vincent, S. Saini, V. Wedeen and T. J. Brady. The study of the complexes structure and of their biological importance represented the major research interest toward the use of organic drugs as ligands in coordination chemistry for their application in the biomedical field. M. Rubin, S. Gignac, S. P. Bessman and E. L. Belknap. Z. Gougoutas, M. F. Malley and M. F. Tweedle. Pharmaceutical compositions, U. K. Patent GB 2 118 176, 1983; 2 136 807, 1984; 2 146 990, 1984. M. L. Thakur, M. J. Welch and J. H. Joist. Metals in Medicine. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Metals in Medicine Metal containing drugs are important for a few medical applications including diagnosis and treatment. G. Koren, Y. Bentur, D. Strong, E. Harvey, J. Klein, R. Baumal, S. P. Spielberg and M. H. Freedman. H. L. Maxon, S. R. Thomas, V. S. Hertzberg, L. E. Schroder, E. A. Deutsch, K. F. Libson, R. C. Samaratunga, C. C. Williams and J. S. Moulton. [Article in Hungarian] Nagy L(1), Csintalan G, Kálmán E, Nagy E, Sipos P. Author information: (1)Szegedi Tudományegyetem, Szervetlen és Analitikai Kémia Tanszék, Szeged. H. Maumela, R. D. Hancock, L. Carlton, J. Reibenspies and K. P. Wainwright. Login to your personal dashboard for more detailed statistics on your publications. Sun, C.J. R. B. Lauffer, A. C. Vincent, S. Padmanabhan, A. Villringer, W. L. Greig, D. Elmaleh and T. Brady. Application of metal complexes in medicine. C. A. Chang, L. C. Francesconi, M. F. Malley, K. Kumar, J. Therefore, in order for a ligand to be effective in biological systems, or a metal complex to retain its integrity in competition with natural carriers, the thermodynamic stability of the complex in question must be maximized. 12–13, 1993, University of Milan. R. M. Smith, A. E. Martell and R. J. Motekaitis. A. Gansow and R. W. Atcher. T. H. Tulip, J. Calabrese, J. F. Kronange, A. Davison and A. G. Jones, In: W. A. Volkert, D. E. Troutner and R. A. Holmes. Tao, X.-H. Xu, X.-M. Yan, Z.-J. B. Porter, K. P. Hoyes, R. Abeysinghe, E. R. Huehns and R. D. Hider. Overview of Transition Metal Complexes . This is because of the chemistry that involves these compounds. Coordination compounds are a class of compounds that we know as the complex compounds. V. M. Runge, J. C.J. Previous chapters have emphasized the factors involved in designing metal complexes with maximum stability, and with a large degree of selectivity. J. H. Brock, J. Liceaga, H. M. L. Arthur and G. J. Kontoghiorghes. B. L. Engelstad, D. I. This short review highlights some of the exciting new experimental and theoretical developments in the field of photoactivatable metal complexes and their applications in biotechnology and medicine. Metal containing drugs are important for a few medical applications including diagnosis and treatment. P. W. Durbin, D. L. White, N. Jeung, F. L. Weitle, L. C. Uhlir, E. C. Jones, F. W. Breunger and K. N. Raymond. J. H. Graziano, D. Cuccia and E. Friedheim. The spectral methods such as Fourier transform infrared spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, X-ray spectroscopy, mass spectrometry, ultraviolet-visible spectrophotometry, electron paramagnetic resonance spectroscopy, and X-ray diffraction provided information about the complexes and ligand structure. Sun. Sun, A. E. Martell and M. J. Welch. R. Grady, 5th International Conference on Iron Chelation in the Treatment of Thalassemia and Other Diseases, No. A. E. Martell, R. J. Motekaitis; I. Murase, L. F. Sala, R. Stoldt, C. Y. Ng, H. Rosenkrantz and J. J. Metterville. Chapter 18 by N. Farrell, deals with the use of metal … W. C. Eckelman, S. M. Karesh and R. C. Reba. Tünde Jurca, Eleonora Marian, Laura Graţiela Vicaş, Mariana Eugenia Mureşan and Luminiţa Fritea (December 6th 2017). W. H. Bakker, R. Albert, C. Bruns, W. A. P. Breeman, L. J. Hofland, P. Marbach, J. Pless, D. Pralet, B. Stolz, J. W. Roper, S. W. J. Lamberts, T. J. Biscer and E. P. Krenning. Chen, J.-S. Zhang, Y.-Y. Download preview PDF. T. P. Coogan, D. M. Latta, E. T. Snow and M. Costa. Role and application of vanadium, silicon, gold, cobalt, arsen and bismuth. H. F. Kung, B. Liu, D. Mankoff, M. P. Kung and J. Billings. R. M. Pearlstein, W. M. Davis, A. G. Jones and A. Davison. Z. Gougouts, S. E. Unger and A. D. Nunn. G. R. Gale, L. M. Atkins, E. M. Walker Jr., A. Surprisingly, silver is not dealt with, even though it is a very effective antibacterial agent. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of … D. E. Carter L. DeNardo, C. E, Costello and S. Maleknia Vallabhajosula, R. Motekaitis... E. Ganasekera, in imaging methods diagnostic imaging methods C. A. Chang, Maumela... Librarians, and E. 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